The effect of diabetes, APOE genotype and its interaction on Lead Investigator: Jie Zhang Institution : Zhongshan Hospital, Fudan University E-Mail : 15111210042@fudan.edu.cn Proposal ID : 876 Proposal Description: We intend to examine the effect of diabetes, APOE genotype and its interaction on cognition,psychiatric symptoms and neuroimaging in older people (including CN, MCI and AD). We will be focusing on these variables, including comprehensive demographics, neuropsychological tests, MRI caculated volumes, subject health history, weight and height, NPI-Q, GDS and APOE genotype.